Upload API calls from within the Bootstrap function

Strapi 4.0.0
Linux Mint 20.2
NPM 8.1.3

Whenever I run an upload API call from within the Bootstrap function, I get an ECONNREFUSED error, but if I make the same call with cURL or POSTMAN, once Strapi is running, it works.

I have no issue with calling the Strapi REST API or query API from within Bootstrap.

Does anyone have/not have this issue? If it is an issue, can we delay Bootstrap until the plugins are up?